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Article

Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure.

Biochemical and biophysical research communications - 4 Jun 2020

Zhou Chengji J, Ji Yu, Reynolds Kurt, McMahon Moira, Garland Michael A, Zhang Shuwen, Sun Bo, Gu Ran, Islam Mohammad, Liu Yue, Zhao Tianyu, Hsu Grace, Iwasa Janet

Abstract excerpt

The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and F-actin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic fate mapping analyses during...

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Identifiers

PMID: 32248972
DOI: 10.1016/j.bbrc.2020.03.138
PMCID: PMC7210071

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