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Article

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends.

Cell reports - 5 Jan 2021

Sharma Sheetal, Anand Roopesh, Zhang Xuzhu, Francia Sofia, Michelini Flavia, Galbiati Alessandro, Williams Hannah, Ronato Daryl A, Masson Jean-Yves, Rothenberg Eli, Cejka Petr, d'Adda di Fagagna Fabrizio

Abstract excerpt

The MRE11-RAD50-NBS1 (MRN) complex supports the synthesis of damage-induced long non-coding RNA (dilncRNA) by RNA polymerase II (RNAPII) from DNA double-strand breaks (DSBs) by an unknown mechanism. Here, we show that recombinant human MRN and native RNAPII are sufficient to reconstitute a minimal functional transcriptional apparatus at DSBs. MRN recruits and stabilizes RNAPII at DSBs. Unexpectedly, transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33406426
DOI: 10.1016/j.celrep.2020.108565
PMCID: PMC7788559

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MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends.PMID 33406426Read ↗

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