Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.

doi:10.1016/j.stemcr.2020.12.008

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Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.

Stem cell reports - 9 Feb 2021

Hayashi Hisamitsu, Osaka Shuhei, Sakabe Kokoro, Fukami Aiko, Kishimoto Eriko, Aihara Eitaro, Sabu Yusuke, Mizutani Ayumu, Kusuhara Hiroyuki, Naritaka Nakayuki, Zhang Wujuan, Huppert Stacey S, Sakabe Masahide, Nakamura Takahisa, Hu Yueh-Chiang, Mayhew Christopher, Setchell Kenneth, Takebe Takanori, Asai Akihiro

Abstract excerpt

The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the intracellular bile acid concentration in human hepatocytes with BSEP deficiency remain unclear. To define pathways that prevent cytotoxic accumulation of bile acid in...

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PMID: 33450190
DOI: 10.1016/j.stemcr.2020.12.008
PMCID: PMC7878720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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