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Article

Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.

The Biochemical journal - 30 Apr 2020

Byrne Matthew J, Nasir Nazia, Basmadjian Christine, Bhatia Chitra, Cunnison Rory F, Carr Katherine H, Mas-Droux Corine, Yeoh Sharon, Cano Céline, Bayliss Richard

Abstract excerpt

Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been observed in several cancers, and inhibition of Nek7 might provide a route to the development of cancer therapeutics. To date, no selective and potent Nek7 inhibitors have been identified. Nek7 crystal structures exhibit an improperly formed regulatory-spine (R-spine), characteristic of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32242624
DOI: 10.1042/BCJ20200128
PMCID: PMC7200626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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