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Article

Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6

24 Oct 2018

Abstract excerpt

Abstract The NIMA (never in mitosis, gene A)-related kinase-6 (NEK6), which is implicated in cell cycle control and plays significant roles in tumorigenesis, is an attractive target for the development of novel anti-cancer drugs. Here we describe the discovery of a potent ATP site-directed inhibitor of NEK6 identified by virtual screening, adopting both structure- and ligand-based techniques. Using a...

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PMID: 30375481
DOI: 10.1038/s41598-018-34471-y

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