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Article

Hypoxia Inducible Factor-1α Inhibition in Von Hippel Lindau-mutant Malignant Pleural Mesothelioma Cells.

Anticancer research - 1 Apr 2020

Shukuya Takehito, Oyanagi Jun, Serizawa Masakuni, Watanabe Masaru, Yamamoto Nobuyuki, Koh Yasuhiro

Abstract excerpt

BACKGROUND/AIM: Molecular targeted agents have been successfully developed against solid tumors and their use is also being investigated for the treatment of malignant pleural mesothelioma (MPM). We have previously reported von Hippel Lindau (VHL) mutations detected by massive parallel sequencing technology in samples of patients with MPM. Here, we conducted an in vitro study to investigate the therapeutic...

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Identifiers

PMID: 32234874
DOI: 10.21873/anticanres.14140

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