Article
Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma.
World journal of surgical oncology - 13 Oct 2010
Foster Jason M, Radhakrishna Uppala, Govindarajan Venkatesh, Carreau Joseph H, Gatalica Zoran, Sharma Poonam, Nath Swapan K, Loggie Brian W
Abstract excerpt
BACKGROUND: There is a paucity of information about the molecular perturbations involved in MPM tumor formation. We previously reported that EGFR-TK mutations in MPM were predictive of achieving optimal surgical cytoreduction, but the status of EGFR pathway activation potential of these mutations was not known. Here we present the mutant EGFR activating potential and the matured survival data of the EGFR...
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