CX3CL1 rs170364 gene polymorphism has a protective effect against major depression by enhancing its transcriptional activity.

doi:10.1016/j.brainres.2020.146801

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Article

CX3CL1 rs170364 gene polymorphism has a protective effect against major depression by enhancing its transcriptional activity.

Brain research - 1 Jul 2020

Peng Qiuju, Shi Lei, Kong Yanying, Yan Yuan, Zhan Jielin, Wen Yuguan, Liu Wenyi, Yu Dexian, Zhou Zhijian, Yan Huacheng

Abstract excerpt

Studies have shown that adult hippocampal neurogenesis may be a cause of depression. CX3CL1 is a chemokine that plays an important role in adult neurogenesis. This study aimed to investigate the relationship between CX3CL1 polymorphisms (rs170364) and the risk of depression. A case-control study of 502 patients with major depression and 504 gender-matched and age-matched healthy controls was performed. All...

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PMID: 32234515
DOI: 10.1016/j.brainres.2020.146801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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