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Cancer carrier screening in the general population using whole-genome sequencing.

Cancer medicine - 1 Jan 2023

Chang Ya-Sian, Chao Dy-San, Chung Chin-Chun, Chou Yu-Pao, Chang Chieh-Min, Lin Chia-Li, Chu Hou-Wei, Chen Hon-Da, Liu Ting-Yuan, Juan Yu-Hsuan, Chang Shun-Jen, Chang Jan-Gowth

Abstract excerpt

BACKGROUND: Cancer is a major cause of death, and its early identification and intervention have potential for clinical actionability and benefits for human health. The studies using whole-genome sequencing (WGS) and large samples analysis of cancer-related genes have been rarely done. METHODS: We performed WGS to explore germline mutations in coding and non-coding areas of cancer-related genes and non-coding...

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PMID: 35861108
DOI: 10.1002/cam4.5034
PMCID: PMC9883534

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