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Evolution of Structural and Functional Diversity of Spexin in Mammalian and Non-mammalian Vertebrate Species

19 Jun 2019

Abstract excerpt

Spexin (SPX) is a novel neuropeptide, which was first identified in the human genome using bioinformatics. Since then, homologues of human SPX have been identified in mammalian and non-mammalian vertebrates; chicken, anole lizard, Nile tilapia, goldfish, zebrafish and fugu. The mature sequence of SPX, NWTPQAMLYLKGAQ, is evolutionally conserved across vertebrate species, with some variation in teleost species...

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PMID: 31275244
DOI: 10.3389/fendo.2019.00379

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