Article
Identifying blood pressure loci whose effects are modulated by multiple lifestyle exposures.
Genetic epidemiology - 1 Sept 2020
Osazuwa-Peters Oyomoare L, Waken R J, Schwander Karen L, Sung Yun Ju, de Vries Paul S, Hartz Sarah M, Chasman Daniel I, Morrison Alanna C, Bierut Laura J, Xiong Chengjie, de las Fuentes Lisa, Rao D C
Abstract excerpt
Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene-multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of...
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