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Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling

11 Jan 2019

Abstract excerpt

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end-stage renal disease in children. Our group has discovered that Holliday Junction resolvase gene Gen1 is a potential candidate gene for CAKUT. Gen1 mutant mice showed CAKUT phenotypes similar to those observed in retinoic acid (RA)-deficient models. The expression of Raldh2, which encodes the key enzyme in RA synthesis, was...

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PMID: 30632787
DOI: 10.1089/dna.2018.4426

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