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Article

Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner

27 Mar 2020

Abstract excerpt

Senescence and mitochondrial stress are mutually reinforcing age-related processes that contribute to idiopathic pulmonary fibrosis (IPF); a lethal disease that manifests primarily in the elderly. Whilst evidence is accumulating that GMP-AMP synthase (cGAS) is crucial in perpetuating senescence by binding damaged DNA released into the cytosol, its role in IPF is not known. The present study examines the...

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PMID: 32219338
DOI: 10.1042/cs20191160

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