Article
Metabolomic Analyses of Brain Tissue in Sepsis Induced by Cecal Ligation Reveal Specific Redox Alterations--Protective Effects of the Oxygen Radical Scavenger Edaravone.
Shock (Augusta, Ga.) - 1 Dec 2015
Hara Naomi, Chijiiwa Miyuki, Yara Miki, Ishida Yusuke, Ogiwara Yukihiko, Inazu Masato, Kuroda Masahiko, Karlsson Michael, Sjovall Fredrik, Elmér Eskil, Uchino Hiroyuki
Abstract excerpt
The pathophysiology of sepsis-associated encephalopathy (SAE) is complex and remains incompletely elucidated. Dysregulated reactive oxygen species (ROS) production and mitochondrial-mediated necrotic-apoptotic pathway have been proposed as part of the pathogenesis. The present study aimed at analyzing the preventive effect of the free radical scavenger edaravone on sepsis-induced brain alterations. Sepsis was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.