Article
Estrogen Receptors (ESRs) Mutations in Adolescent Idiopathic Scoliosis: A Cross-Sectional Study.
Medical science monitor : international medical journal of experimental and clinical research - 16 Mar 2020
Wang Lianlei, Zhang Yuanqiang, Zhao Sen, Dong Xiying, Li Xiaoxin, You Yi, Yan Zihui, Liu Gang, Tong Bingdu, Chen Yaping, Yang Xu, Tian Yuan, Gao Na, Wang Yipeng, Wu Zhihong, Qiu Guixing, Zhang Jianguo, Wu Nan, Deciphering Disorders Involving Scoliosis COmorbidities Disco Study Group
Abstract excerpt
BACKGROUND Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, but its etiology is unclear. Multiple genetic mutations have been reported to be associated with AIS. MATERIAL AND METHODS We enrolled a cohort of 113 surgically treated AIS patients with available parental subjects from the Peking Union Medical College Hospital. We performed whole-exome sequencing in 10 trio families and...
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