Article
The Role of MECP2 and CCR5 Polymorphisms on the Development and Course of Systemic Lupus Erythematosus.
Biomolecules - 24 Mar 2020
Rzeszotarska Ewa, Sowinska Anna, Stypinska Barbara, Walczuk Ewa, Wajda Anna, Lutkowska Anna, Felis-Giemza Anna, Olesinska Marzena, Puszczewicz Mariusz, Majewski Dominik, Jagodzinski Pawel Piotr, Czerewaty Michal, Malinowski Damian, Pawlik Andrzej, Jaronczyk Malgorzata, Paradowska-Gorycka Agnieszka
Abstract excerpt
Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease. SLE is described by production of autoantibodies and causes damage of many organs. T-cells play a crucial role in SLE pathogenesis. T-cells intensify inflammation through a number of processes, which leads to autoimmunization. CCR5 and MECP2 genes are linked with T-cells and pathogenesis of SLE. Polymorphisms in these genes are...
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