Article
The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis.
Cell reports - 24 Mar 2020
Mesquita Inês, Ferreira Carolina, Moreira Diana, Kluck George Eduardo Gabriel, Barbosa Ana Margarida, Torrado Egídio, Dinis-Oliveira Ricardo Jorge, Gonçalves Luís Gafeira, Beauparlant Charles-Joly, Droit Arnaud, Berod Luciana, Sparwasser Tim, Bodhale Neelam, Saha Bhaskar, Rodrigues Fernando, Cunha Cristina, Carvalho Agostinho, Castro António Gil, Estaquier Jérôme, Silvestre Ricardo
Abstract excerpt
Hypoxia-inducible factor-1 alpha (HIF-1α) is considered a global regulator of cellular metabolism and innate immune cell functions. Intracellular pathogens such as Leishmania have been reported to manipulate host cell metabolism. Herein, we demonstrate that myeloid cells from myeloid-restricted HIF-1α-deficient mice and individuals with loss-of-function HIF1A gene polymorphisms are more susceptible to L. donovani...
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