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Article

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

30 Nov 2017

Abstract excerpt

Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is activated by Leishmania and this pathway is important for Leishmania amazonensis infection. Knocking down PERK or ATF4 expression or inhibiting PERK kinase activity...

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PMID: 29213084
DOI: 10.1038/s41598-017-17252-x

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