Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner

22 Aug 2019

Abstract excerpt

Cutaneous leishmaniasis is characterized by vascular remodeling. Following infection with Leishmania parasites, the vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway mediates lymphangiogenesis, which is critical for lesion resolution. Therefore, we investigated the cellular and molecular mediators involved in VEGF-A/VEGFR-2 signaling using a murine model of infection.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers in Disease Mechanisms
Share to Endometriosis Research and Treatment
Share to Research on Leishmaniasis Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31451620
DOI: 10.1128/iai.00088-19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent MannerPMID 31451620Read ↗

<i>Leishmania major</i> Infection–Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls DiseaseSemantic proximity Read ↗

HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infectionSemantic proximity Read ↗

Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropicaSemantic proximity Read ↗

Immune Responses in Leishmaniasis: An OverviewSemantic proximity Read ↗

Leishmania donovani-Induced Prostaglandin E2 Generation Is Critically Dependent on Host Toll-Like Receptor 2–Cytosolic Phospholipase A2 SignalingSemantic proximity Read ↗

Leishmania-macrophage interactions: multiple receptors, multiple ligands and diverse cellular responsesSemantic proximity Read ↗

Toll-Like Receptors in AngiogenesisSemantic proximity Read ↗

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasisSemantic proximity Read ↗

Effect of Leishmania RNA virus 2 on virulence factors and cytokines gene expression in a human macrophage infected with Leishmania major: A preliminary studySemantic proximity Read ↗

FasL and TRAIL signaling in the skin during cutaneous leishmaniasis - implications for tissue immunopathology and infectious controlSemantic proximity Read ↗

Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil.Semantic proximity Read ↗

MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.