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Article

A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants.

Viruses - 19 Mar 2020

Makau Juliann Nzembi, Watanabe Ken, Otaki Hiroki, Mizuta Satoshi, Ishikawa Takeshi, Kamatari Yuji O, Nishida Noriyuki

Abstract excerpt

The emergence of resistance to currently available anti-influenza drugs has heightened the need for antivirals with novel mechanisms of action. The influenza A virus (IAV) nucleoprotein (NP) is highly conserved and essential for the formation of viral ribonucleoprotein (vRNP), which serves as the template for replication and transcription. Recently, using in silico screening, we identified an antiviral compound...

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Share to Gene Expression Regulation, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza, Human

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Source

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Identifiers

PMID: 32204549
DOI: 10.3390/v12030337
PMCID: PMC7150793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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