Article
Single nucleoprotein residue determines influenza A virus sensitivity to an intertypic suppression mechanism.
Virology - 1 Jun 2017
Narkpuk Jaraspim, Teeravechyan Samaporn, Puthavathana Pilaipan, Jongkaewwattana Anan, Jaru-Ampornpan Peera
Abstract excerpt
Several mechanisms underlying intertypic interference between co-infecting influenza types A and B viruses (IAV and IBV) have been proposed. We have recently described one in which IBV's nucleoprotein (BNP) sequestered IAV's nucleoprotein (ANP) and suppressed IAV polymerase and growth. However, its anti-IAV capacity and limitations have not been fully explored. Here, we showed that BNP's inhibitory effect was...
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