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Article

Parallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitors.

PloS one - 1 Jan 2013

Hsu Kai-Cheng, Hung Hui-Chen, Horng Jim-Tong, Fang Ming-Yu, Chang Chun-Yu, Li Ling-Ting, Chen I-Jung, Chen Yun-Chu, Chou Ding-Li, Chang Chun-Wei, Hsieh Hsing-Pang, Yang Jinn-Moon, Hsu John T-A

Abstract excerpt

Infection with influenza virus is a major public health problem, causing serious illness and death each year. Emergence of drug-resistant influenza virus strains limits the effectiveness of drug treatment. Importantly, a dual H275Y/I223R mutation detected in the pandemic influenza A 2009 virus strain results in multidrug resistance to current neuraminidase (NA) drugs. Therefore, discovery of new agents for...

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Identifiers

PMID: 23437217
DOI: 10.1371/journal.pone.0056704
PMCID: PMC3577712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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