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Article

The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting.

Blood advances - 24 Mar 2020

Juliusson Gunnar, Jädersten Martin, Deneberg Stefan, Lehmann Sören, Möllgård Lars, Wennström Lovisa, Antunovic Petar, Cammenga Jörg, Lorenz Fryderyk, Ölander Emma, Lazarevic Vladimir Lj, Höglund Martin

Abstract excerpt

In acute myeloid leukemia (AML) FLT3 internal tandem duplication (ITD) and nucleophosmin 1 (NPM1) mutations provide prognostic information with clinical relevance through choice of treatment, but the effect of age and sex on these molecular markers has not been evaluated. The Swedish AML Registry contains data on FLT3-ITD and NPM1 mutations dating to 2007, and 1570 adult patients younger than 75 years, excluding...

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Identifiers

PMID: 32203582
DOI: 10.1182/bloodadvances.2019001335
PMCID: PMC7094014

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