Article
Process genes list: An approach to link genetics and human brain imaging.
Journal of neuroscience methods - 1 Jun 2020
Poblete Guillermo F, Gosnell Savannah N, Meyer Matthew, Fang Mary, Nguyen Tien, Patriquin Michelle A, Nielsen David, Kosten Thomas, Salas Ramiro
Abstract excerpt
BACKGROUND: Linking human genetics and brain imaging data is extremely challenging, among other reasons because both fields suffer from multiple comparison problems. NEW METHOD: ProcessGeneLists (PGL) links genetics and human brain imaging by using genes associated with a disease and calculating a normalized mRNA expression average of those genes in each brain region. Brain regions in which those genes are most...
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