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Non-clinical safety considerations on genome editing using the CRISPR/Cas system

28 Jul 2025

Abstract excerpt

Recent advances in gene editing using the CRISPR/Cas system have revolutionized genome editing, opening new horizons for human cellular and gene therapy products. Genome editing technologies are rapidly being adopted in clinical trials; however, critical non-clinical safety considerations are required to address challenges in translating research to the clinic. Here, we review current ex vivo and in vivo genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41362674
DOI: 10.1016/j.gendis.2025.101785

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