Article
The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3.
The Journal of biological chemistry - 17 Apr 2020
Ren Jianwei, Liu Yi, Wang Shanshan, Wang Yu, Li Wende, Chen Siyu, Cui Dexuan, Yang Shengli, Li Ming-Yue, Feng Bo, Lai Paul B S, Chen George G
Abstract excerpt
The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA...
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