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Article

ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.

Molecular cell - 7 May 2020

Yoshida Keisuke, Maekawa Toshio, Ly Nhung Hong, Fujita Shin-Ichiro, Muratani Masafumi, Ando Minami, Katou Yuki, Araki Hiromitsu, Miura Fumihito, Shirahige Katsuhiko, Okada Mariko, Ito Takashi, Chatton Bruno, Ishii Shunsuke

Abstract excerpt

Paternal dietary conditions may contribute to metabolic disorders in offspring. We have analyzed the role of the stress-dependent epigenetic regulator cyclic AMP-dependent transcription factor 7 (ATF7) in paternal low-protein diet (pLPD)-induced gene expression changes in mouse liver. Atf7+/- mutations cause an offspring phenotype similar to that caused by pLPD, and the effect of pLPD almost vanished when...

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PMID: 32197065
DOI: 10.1016/j.molcel.2020.02.028

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