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Article

Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7

30 Oct 2018

Abstract excerpt

Various stresses increase disease susceptibility and accelerate aging, and increasing evidence suggests that these effects can be transmitted over generation. Epidemiological studies suggest that stressors experienced by parents affect the longevity of their offspring, possibly by regulating telomere dynamics. Telomeres are elongated by telomerase and shortened by certain stresses as well as telomere...

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Share to Chromosomal and Genetic Variations
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30407559
DOI: 10.1093/nar/gky1149

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