Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications

20 Mar 2020

Abstract excerpt

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Monoclonal and Polyclonal Antibodies Research
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32193207
DOI: 10.1074/jbc.ra120.012791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applicationsPMID 32193207Read ↗

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1Semantic proximity Read ↗

Novel humanized monoclonal antibodies against ROR1 for cancer therapySemantic proximity Read ↗

Humanization of rabbit monoclonal antibodies via grafting combined Kabat/IMGT/Paratome complementarity-determining regions: Rationale and examplesSemantic proximity Read ↗

Therapeutic Potential and Challenges of Targeting Receptor Tyrosine Kinase ROR1 with Monoclonal Antibodies in B-Cell MalignanciesSemantic proximity Read ↗

Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network.Semantic proximity Read ↗

Impact of humanization scaffold design on the functional activity of FGFR2-targeting chicken scFvs.Semantic proximity Read ↗

Reliable energy-based antibody humanization and stabilizationSemantic proximity Read ↗

Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discoverySemantic proximity Read ↗

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire miningSemantic proximity Read ↗

Dramatic Activation of an Antibody by a Single Amino Acid Change in FrameworkSemantic proximity Read ↗

Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificitySemantic proximity Read ↗

From rabbit antibody repertoires to rabbit monoclonal antibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.