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Article

A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.

Journal of virology - 1 Mar 2014

Silva Laurie A, Khomandiak Solomiia, Ashbrook Alison W, Weller Romy, Heise Mark T, Morrison Thomas E, Dermody Terence S

Abstract excerpt

UNLABELLED: Chikungunya virus (CHIKV) is a reemerging arbovirus responsible for outbreaks of infection throughout Asia and Africa, causing an acute illness characterized by fever, rash, and polyarthralgia. Although CHIKV infects a broad range of host cells, little is known about how CHIKV binds and gains access to the target cell interior. In this study, we tested whether glycosaminoglycan (GAG) binding is...

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Identifiers

PMID: 24371059
DOI: 10.1128/JVI.03116-13
PMCID: PMC3958064

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