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Article

Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.

Communications biology - 18 Mar 2020

Wuggenig Philipp, Kaya Berna, Melhem Hassan, Ayata C Korcan, Hruz Petr, Sayan A Emre, Tsumura Hideki, Ito Morihiro, Roux Julien, Niess Jan Hendrik

Abstract excerpt

Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function of branched-chain amino acids in the development of gut macrophages, an inducible knock-out mouse model for the branched-chain amino acid transporter CD98hc in CX3CR1+ macrophages was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32188932
DOI: 10.1038/s42003-020-0842-3
PMCID: PMC7080761

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