Article
Gray Areas in the Gray Matter: IDH1/2 Mutations in Glioma.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 Mar 2020
van den Bent Martin J, Mellinghoff Ingo K, Bindra Ranjit S
Abstract excerpt
Since the first discovery of isocitrate dehydrogenase (IDH) mutations in cancer, considerable progress has been made in our understanding of their contribution to cancer development. For glioma, this has helped to identify two diagnostic groups of tumors (oligodendroglioma and astrocytoma IDHmt) with distinct clinical characteristics and that are now diagnosed by the presence of the IDH mutations. The metabolic...
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