Article
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection.
mBio - 17 Mar 2020
Haga Kei, Ettayebi Khalil, Tenge Victoria R, Karandikar Umesh C, Lewis Miranda A, Lin Shih-Ching, Neill Frederick H, Ayyar B Vijayalakshmi, Zeng Xi-Lei, Larson Göran, Ramani Sasirekha, Atmar Robert L, Estes Mary K
Abstract excerpt
Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and epidemiologic studies that show an association of secretor status with infection caused by several genotypes. The fucosyltransferase 2 gene (FUT2) affects HBGA expression in...
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