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Article

Replication of human noroviruses in stem cell–derived human enteroids

25 Aug 2016

Abstract excerpt

The major barrier to research and development of effective interventions for human noroviruses (HuNoVs) has been the lack of a robust and reproducible in vitro cultivation system. HuNoVs are the leading cause of gastroenteritis worldwide. We report the successful cultivation of multiple HuNoV strains in enterocytes in stem cell-derived, nontransformed human intestinal enteroid monolayer cultures. Bile, a critical...

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PMID: 27562956
DOI: 10.1126/science.aaf5211

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