A Homozygous Nonsense Mutation (428G→A) in the Human Secretor ( <i>FUT2</i> ) Gene Provides Resistance to Symptomatic Norovirus (GGII) Infections

Abstract excerpt

Noroviruses (formerly Norwalk-like viruses) are a major cause of acute gastroenteritis worldwide and are associated with a significant number of nosocomial and food-borne outbreaks. In this study we show that the human secretor FUT2 gene, which codes for an alpha(1,2)-fucosyltransferase synthesizing the H-type 1 antigen in saliva and mucosa, is associated with susceptibility to norovirus infections. Allelic...

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