A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.

doi:10.1210/jc.2016-2368

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.

The Journal of clinical endocrinology and metabolism - 1 Nov 2016

Pazderska Agnieszka, Oftedal Bergithe E, Napier Catherine M, Ainsworth Holly F, Husebye Eystein S, Cordell Heather J, Pearce Simon H S, Mitchell Anna L

Abstract excerpt

CONTEXT: Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions. OBJECTIVE: We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD. DESIGN, SETTING, AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Addison Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Basic-Leucine Zipper Transcription Factors

Share to Cohort Studies

Share to Genetic Association Studies

Share to Norway

Share to Polyendocrinopathies, Autoimmune

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 27680876
DOI: 10.1210/jc.2016-2368
PMCID: PMC5095240

Genes

BACH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans.PMID 27680876Read ↗

Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's diseaseSemantic proximity Read ↗

Polymorphism in BACH2 gene is a marker of polyglandular autoimmunitySemantic proximity Read ↗

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibilitySemantic proximity Read ↗

Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts.Semantic proximity Read ↗

CTLA-4 as a genetic determinant in autoimmune Addison's disease.Semantic proximity Read ↗

Rare copy number variation in autoimmune Addison's disease.Semantic proximity Read ↗

CYP21A2 polymorphisms in patients with autoimmune Addison's disease, and linkage disequilibrium to HLA risk alleles.Semantic proximity Read ↗

Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease in Sweden.Semantic proximity Read ↗

Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison’s Disease and Graves’ Disease SusceptibilitySemantic proximity Read ↗

Genetic polymorphisms of BACH2, a key gene regulating Th2 immune response, increasing risk of allergic rhinitis.Semantic proximity Read ↗

Autoimmune Addison disease: pathophysiology and genetic complexity.Semantic proximity Read ↗

Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.