Article
Structural organization and interactions of transmembrane domains in tetraspanin proteins.
BMC structural biology - 28 Jun 2005
Kovalenko Oleg V, Metcalf Douglas G, DeGrado William F, Hemler Martin E
Abstract excerpt
BACKGROUND: Proteins of the tetraspanin family contain four transmembrane domains (TM1-4) linked by two extracellular loops and a short intracellular loop, and have short intracellular N- and C-termini. While structure and function analysis of the larger extracellular loop has been performed, the organization and role of transmembrane domains have not been systematically assessed. RESULTS: Among 28 human...
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