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Article

A phenotypic approach to probing cellular outcomes using heterobivalent constructs.

Chemical communications (Cambridge, England) - 18 Apr 2020

Bhadoria Rohit, Ping Kefeng, Lohk Christer, Järving Ivar, Starkov Pavel

Abstract excerpt

Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cell viability and...

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Identifiers

PMID: 32181457
DOI: 10.1039/c9cc09595k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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