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Article

Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.

Nature biotechnology - 1 Nov 2005

Weissleder Ralph, Kelly Kimberly, Sun Eric Yi, Shtatland Timur, Josephson Lee

Abstract excerpt

Nanomaterials with precise biological functions have considerable potential for use in biomedical applications. Here we investigate whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of such nanomaterials. We describe the parallel synthesis of a library comprising 146 nanoparticles decorated with different synthetic small molecules. Using...

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PMID: 16244656
DOI: 10.1038/nbt1159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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