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Article

Novel surface tagging technology for selection of complex proliferation-controlled mammalian cell phenotypes.

Biotechnology and bioengineering - 5 Dec 2001

Schlatter S, Bailey J E, Fussenegger M

Abstract excerpt

Regulated overexpression of the cyclin dependent kinase inhibitor p27 enables biphasic production processes which consist of a nonproducing expansion phase followed by an extended proliferation-arrested production phase. During the growth-arrested production phase proliferation-competent mutants emerge as a consequence of genetic drift and strong counterselection. Here, we evaluate the use of cell surface markers...

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PMID: 11745136
DOI: 10.1002/bit.1189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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