Article
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort.
Molecular metabolism - 1 Apr 2020
Kulyté Agné, Lundbäck Veroniqa, Lindgren Cecilia M, Luan Jian'an, Lotta Luca A, Langenberg Claudia, Arner Peter, Strawbridge Rona J, Dahlman Ingrid
Abstract excerpt
OBJECTIVES: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes. The goal of this study was to identify the genetic regulators of lipolysis and elucidate their molecular mechanisms. METHODS: Adipocytes from abdominal subcutaneous adipose tissue biopsies were isolated...
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