Article
IL-28B variant as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy.
Journal of gastroenterology and hepatology - 1 Oct 2020
Terashima Takeshi, Honda Masao, Toyama Tadashi, Shimakami Tetsuro, Shimizu Ryogo, Takatori Hajime, Arai Kuniaki, Kawaguchi Kazunori, Kitamura Kazuya, Yamashita Taro, Sakai Yoshio, Yamashita Tatsuya, Mizukoshi Eishiro, Kaneko Shuichi
Abstract excerpt
BACKGROUND AND AIM: Single-nucleotide polymorphisms (SNPs) of the interleukin-28B (IL-28B) gene are associated with the effectiveness of interferon therapy for chronic hepatitis C infection. Whether the IL-28B genotype affects the course of treatment and the outcomes of patients with advanced hepatocellular carcinoma (HCC) is unknown. METHODS: We detected the IL-28B SNP (rs8099917) using TaqMan PreDesigned SNP...
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