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Article

Screening for IL28B gene variants identifies predictors of hepatitis C therapy success.

Antiviral therapy - 1 Jan 2010

Doehring Alexandra, Hofmann Wolf Peter, Schlecker Christina, Zeuzem Stefan, Susser Simone, Geisslinger Gerd, Sarrazin Christoph, Lötsch Jörn

Abstract excerpt

BACKGROUND: Recent research has shown that genetic variation in the IL28B gene predicts both chronicity of HCV infection and sustained virological response (SVR) to antiviral standard therapy. Because HCV affects 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular...

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Source

Identifiers

PMID: 21149916
DOI: 10.3851/IMP1689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21149916-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Screening for IL28B gene variants identifies predictors of hepatitis C therapy success.PMID 21149916Read ↗

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.Semantic proximity Read ↗

IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection.Semantic proximity Read ↗

A genetic variant in the interleukin 28B gene as a major predictor for sustained virologic response in chronic hepatitis C virus infection.Semantic proximity Read ↗

Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data.Semantic proximity Read ↗

IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice.Semantic proximity Read ↗

Role of interleukin 28B-related gene polymorphisms in chronic hepatitis C and the response to antiviral therapy in Koreans.Semantic proximity Read ↗

Role of interleukin-28B genetic polymorphisms in Korean patients with hepatitis C virus infection.Semantic proximity Read ↗

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.Semantic proximity Read ↗

IL28B genetic variations are associated with treatment response of patients with chronic hepatitis C in a Chinese Han population.Semantic proximity Read ↗

IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients.Semantic proximity Read ↗

Rs12979860 and rs8099917 single nucleotide polymorphisms of interleukin-28B gene: simultaneous genotyping in caucasian patients infected with hepatitis C virus.Semantic proximity Read ↗

Development and Validation of a Simple, Rapid and Inexpensive PCRRFLP Method for Genotyping of Common IL28B Polymorphisms: A Useful Pharmacogenetic Tool for Prediction of Hepatitis C Treatment ResponseSemantic proximity Read ↗

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