Article
Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons.
eLife - 16 Mar 2020
Luo Jiangnan, Ting Chun-Yuan, Li Yan, McQueen Philip, Lin Tzu-Yang, Hsu Chao-Ping, Lee Chi-Hon
Abstract excerpt
Establishing appropriate sizes and shapes of dendritic arbors is critical for proper wiring of the central nervous system. Here we report that Insulin-like Peptide 2 (DILP2) locally activates transiently expressed insulin receptors in the central dendrites of Drosophila Dm8 amacrine neurons to positively regulate dendritic field elaboration. We found DILP2 was expressed in L5 lamina neurons, which have axonal...
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