Article
Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers.
Scientific reports - 12 Mar 2020
Faraj Bayan H A, Collard Liam, Cliffe Rachel, Blount Leanne A, Lonnen Rana, Wallis Russell, Andrew Peter W, Hudson Andrew J
Abstract excerpt
Oligomers of pneumolysin form transmembrane channels in cholesterol-containing lipid bilayers. The mechanism of pore formation involves a multistage process in which the protein, at first, assembles into a ring-shaped complex on the outer-bilayer leaflet. In a subsequent step, the complex inserts into the membrane. Contrary to most investigations of pore formation that have focussed on protein changes, we have...
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