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Article

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.

Science (New York, N.Y.) - 13 Mar 2020

Loganathan Sampath K, Schleicher Krista, Malik Ahmad, Quevedo Rene, Langille Ellen, Teng Katie, Oh Robin H, Rathod Bhavisha, Tsai Ricky, Samavarchi-Tehrani Payman, Pugh Trevor J, Gingras Anne-Claude, Schramek Daniel

Abstract excerpt

In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent but infrequent "long tail" mutations are often unknown. We focused on 484 long tail genes in head and neck squamous cell carcinoma (HNSCC) and used in vivo CRISPR to screen for genes that, upon mutation, trigger tumor development in mice. Of the 15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32165588
DOI: 10.1126/science.aax0902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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