Article
Robust pathway sampling in phenotype prediction. Application to triple negative breast cancer.
BMC bioinformatics - 11 Mar 2020
Cernea Ana, Fernández-Martínez Juan Luis, deAndrés-Galiana Enrique J, Fernández-Ovies Francisco Javier, Alvarez-Machancoses Oscar, Fernández-Muñiz Zulima, Saligan Leorey N, Sonis Stephen T
Abstract excerpt
BACKGROUND: Phenotype prediction problems are usually considered ill-posed, as the amount of samples is very limited with respect to the scrutinized genetic probes. This fact complicates the sampling of the defective genetic pathways due to the high number of possible discriminatory genetic networks involved. In this research, we outline three novel sampling algorithms utilized to identify, classify and...
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