Probabilistic reconstruction of the tumor progression process in gene regulatory networks in the presence of uncertainty.

Abstract excerpt

BACKGROUND: Accumulation of gene mutations in cells is known to be responsible for tumor progression, driving it from benign states to malignant states. However, previous studies have shown that the detailed sequence of gene mutations, or the steps in tumor progression, may vary from tumor to tumor, making it difficult to infer the exact path that a given type of tumor may have taken. RESULTS: In this paper, we...

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