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Article

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

13 Nov 2020

Abstract excerpt

Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in mitochondrial function caused by the defective clearance of mitochondria. Several studies have demonstrated that parkin dysfunction causes mitochondrial injury and astrocytic...

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PMID: 33298969
DOI: 10.1038/s41531-020-00137-8

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