Article
A preliminary computational outputs versus experimental results: Application of sTRAP, a biophysical tool for the analysis of SNPs of transcription factor-binding sites.
Molecular genetics & genomic medicine - 1 May 2020
Moradifard Shirin, Saghiri Reza, Ehsani Parastoo, Mirkhani Fatemeh, Ebrahimi-Rad Mina
Abstract excerpt
BACKGROUND: In the human genome, the transcription factors (TFs) and transcription factor-binding sites (TFBSs) network has a great regulatory function in the biological pathways. Such crosstalk might be affected by the single-nucleotide polymorphisms (SNPs), which could create or disrupt a TFBS, leading to either a disease or a phenotypic defect. Many computational resources have been introduced to predict the...
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